Protecting groups in organic synthesis

Author: (USA) Green, (USA) Woods, translated by the Organic Chemistry Teaching and Research Group of East China University of Science and Technology
Publisher:
Publish Date: 2004-10-01
Features: The book is organized by functional groups, providing concise descriptions and reviews of various protection/deprotection methods. Additionally, it lists over 5,400 original references to help readers access comprehensive information and experimental conditions related to the processes. The first chapter of the book discusses general aspects of protecting group chemistry: the properties of protecting groups, the development of new protecting groups, how to select a protecting group from those discussed in the book, and the use of protecting groups in the Brefeldin synthesis. The book is organized according to the functional groups being protected, with possible protecting groups listed at the beginning of each chapter. Within each chapter, protecting groups are arranged based on their structural complexity (e.g., methyl, ethyl, t-butyl benzyl). Effective generation or cleavage methods are introduced first. The focus is on recent literature, as older methods may have been improved. Therefore, original literature may not be included, and I apologize to the authors who have contributed but have not been recognized. Chapter 8 explains the relationship between reaction activity and reagents, with reaction schemes organized by each protecting group family.