Chromatography-mass spectrometry (LC-MS)

Author: Sheng Longsheng
Publisher:
Publish Date: 2006-02-01
Features: As an online coupling technology, the most commonly used methods are gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) coupling technology. GC/MS should be the preferred method in chromatography/mass spectrometry coupling technology. In Chapter, the focus is on the basic principles of gas chromatography/mass spectrometry coupling technology; gas chromatography and mass spectrometry instruments and key points of operation; data acquisition and processing; spectral library retrieval and typical application examples, to help readers master the basic theory, methods, and techniques of mass spectrometry. LC/MS is suitable for the separation and analysis of polar, thermally unstable, difficult to gasify, and large molecules. In the second chapter on liquid chromatography/mass spectrometry coupling technology, the focus is on the principle of ESI and the interface technology with LC and MS. Relevant methods, techniques, and new developments are discussed in combination with application examples. This book is suitable for scientific and technical personnel engaged in mass spectrometry analysis and the study of material structure and composition for reference. This book is divided into two chapters: "Gas Chromatography-Mass Spectrometry Coupling Technology" and "Liquid Chromatography-Mass Spectrometry Coupling Technology." Chapter focuses on the basic principles of gas chromatography-mass spectrometry, various chromatography and mass spectrometry instruments and key points of operation, data acquisition and processing, spectral library retrieval, and typical application examples; the second chapter focuses on the principle of ESI and the interface technology with LC and MS, as well as the introduction of relevant methods, techniques, and new development examples.