Who is more prone to chromosomal abnormalities?

Patient's question:

Doctor, when my friend was checked for infertility, they found chromosomal abnormalities, which may interfere with having children. But when we touch her normally, she seems fine. I want to ask which people are prone to chromosomal abnormalities?

Doctor's answer:

Chromosomal abnormalities, some of which are inherited from parents across generations, some are caused by chromosomal variations during embryonic development, and some are induced by severe chromosomal changes after long-term exposure to toxic and harmful substances.
People who are prone to experiencing chromosomal abnormalities include those with a family history of genetic disorders, developmental and growth disorders, intellectual disabilities, multiple congenital malformations, primary infertility, primary amenorrhea, severe oligoasthenozoospermia or azoospermia, etc. Among individuals with chromosomal abnormalities, a small proportion exhibit no abnormalities themselves but still experience infertility or recurrent miscarriages, making it difficult to conceive healthy offspring.

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