Patient's question:
A 34-year-old woman and her husband previously had one pregnancy, but it ended in a miscarriage. Recently, they are trying to conceive again, but I found out yesterday that I have chromosomal abnormalities. I'm told this could lead to a miscarriage if I do get pregnant. Online says chromosomal abnormalities come in several types. I want to understand, which chromosome abnormality is the most severe?Doctor's answer:
Chromosomes are the carriers of genes, and chromosomal abnormalities can lead to abnormal gene expression and abnormal growth and development of the body. The pathogenesis of chromosomal aberrations is not yet clear, and it may be caused by the failure of chromosomes to fuse again during the late stage of cell division, or by the fragmentation and reconnection of chromosomes under various internal and external factors. Some chromosomal abnormalities are merely polymorphisms or markers of hereditary transmission across generations, and they will never cause infertility, miscarriage, or embryonic arrest.