Can embryos with chromosomal abnormalities undergo artificial insemination?

Patient's question:

I have carefully checked for chromosomal abnormalities in the embryo, and this time the thorough examination also revealed some issues with autoimmune factors, specifically a weakly positive antinuclear antibody. Previously, I had three natural miscarriages, with the last one occurring in 2016, and now this is the fourth miscarriage. Will artificial insemination be affected?

Doctor's answer:

This issue is quite tricky. A typical case of recurrent Kleine-Levin syndrome in cats is caused by a partial deletion of chromosome 5, which is mostly due to external factors. So, if both of you have normal chromosomes, then this Kleine-Levin syndrome must be caused by some factor or environmental effect leading to a sudden chromosomal mutation—a situation. After removing the external triggers, the next early pregnancy may not have this problem.

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