Which diseases are prone to cause habitual abortion in women?

Patient's question:

Why can't I get pregnant three times? I've had multiple miscarriages, but why can't I get pregnant? Which diseases are prone to cause habitual abortion in women?

Doctor's answer:

1. Luteal phase defect If the corpus luteum function is incomplete, it cannot function properly, leading to abnormal endometrium and endocrine disorders, as well as low secretion function of the corpus luteum, resulting in insufficient progesterone secretion. The endometrium may fail to respond properly or exhibit poor decidual reaction after early pregnancy, making it difficult for the embryo to implant or affecting its development after implantation, ultimately causing miscarriage.
2. Uterine developmental abnormalities The uterus is the site where the embryo implants, develops, and grows, serving as the soil for embryonic development. Uterine abnormalities prevent the embryo from developing normally, leading to miscarriage. Therefore, uterine developmental abnormalities can cause habitual abortion.
3. Chromosomal abnormalities Fertilization is not simply the combination of sperm and egg. Additionally, 23 pairs of chromosomes must successfully combine to form an embryo. In this complex process, a small error can lead to severe genetic variation, such as chromosomal abnormalities. The direct result of genetic variation is that the embryo cannot survive. Therefore, chromosomal abnormalities are a major factor or cause of miscarriage.

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