Patient's question:
Medical history: In February 2009, after 3 years of marriage, she was diagnosed with polycystic ovary syndrome during a check-up. Symptoms: obesity, heavy body hair, and acne. Previous treatment and effectiveness: Initially, she took Dian-35 orally, which regulated her menstrual cycle but did not result in pregnancy. Later, she took clomiphene orally, but still remained infertile. Desired help: How should we treat this now?Doctor's answer:
Polycystic ovary syndrome (PCOS) is a relatively common endocrine syndrome among women of reproductive age, not a distinct disease but rather a heterogeneous clinical syndrome with multiple etiologies. It is generally believed to be associated with dysfunction of the hypothalamic-pituitary-ovarian axis, adrenal gland disorders, genetic factors, metabolic factors, and others. A small number of PCOS patients have sex chromosome or autosomal abnormalities, and some have a family history. The pathogenesis of PCOS is complex, and it is widely recognized that: ① High LH with normal or low levels of FSH; ② Elevated androgens; ③ Consistent estrogen levels (E1 higher than E2); ④ Insulin resistance (hyperinsulinemia); ⑤ Morphological changes in ovarian tissue, including multiple cystic follicles and stromal hyperplasia. Based on your description, the presence of polycystic ovary ultrasound findings does not necessarily mean you have PCOS. It is recommended that you visit a regular hospital and consult a gynecological endocrinology specialist, combining hormone tests and clinical symptoms for further diagnosis.