Alzheimer's Disease Pathogenesis - ABC Hypothesis

Author: Li Wenbin Wang Lunin
Publisher:
Publish Date: 2005-01-01
Features: This is a highly specialized academic monograph on the pathogenesis of Alzheimer's dementia. The authors are basic and clinical researchers engaged in this topic. Using the three English letters A, B, and C to represent factors related to three major categories of pathological and physiological changes in dementia—brain aging, amyloid-beta, and neurotransmitter receptor channels—the authors express their views on the causes and mechanisms of Alzheimer's dementia: brain aging serves as the foundation, background, and condition for dementia onset; Aβ is the key damaging factor in dementia; oxidative stress is the initiating factor for brain aging; free radicals, when combined with or complementary to Aβ, preferentially damage neurotransmitter receptors, leading to imbalances in brain neural circuits, disrupting the integration of neural and psychological functions, and ultimately causing the disease. The features of this monograph are: First, the academic perspectives expressed by the authors are a scientific summary of their 20 years of research in this field, based on extensive and systematic experimental data; Second, the content of this monograph aligns with the forefront and mainstream of contemporary scientific development, demonstrating unique insights or new discoveries in certain aspects; Third, it is highly practical, providing valuable academic insights and research platforms for the development of aging neurobiology; Fourth, the monograph is self-contained, integrating achievements from multiple disciplines and technical methods, conducting multi-level experimental research, and comprehensively summarizing the rational thinking and operational models of characteristic scientific research. Therefore, this monograph serves as a reference for basic and clinical researchers in neurology and psychiatry, as well as for specialized personnel engaged in research in this field.