Biological Adhesive Drug Delivery System—Basic Principles, New Methods, and Advances

Author: (USA) Mathiowitz
Publisher:
Publish Date: 2006-01-01
Features: About this book: This important reference book comprehensively reviews the fundamental methods for characterizing bioadhesive materials and improving drug delivery carriers, enabling the preparation of novel drug formulations using existing compounds at lower R&D costs through repurposing. The book is authored by over 50 internationally renowned experts, reflecting broad knowledge—both traditional bioadhesive techniques and novel clinical applications. It discusses mechanics and chemical bonding, polymer-mucilage interactions, the influence of surface energy on bioadhesion, polymer hydration, and mucilage rheology. It analyzes the physicochemical properties of mucilage and glycoproteins, cell adhesion molecules, and the interaction between cells and two-dimensional and three-dimensional surfaces. It covers methods such as microbalances, magnetic sensors, atomic force microscopy, direct measurement of molecular-level adhesion, and measurement of intercellular interactions. It examines bioadhesive carriers, diffusion or penetration enhancers, and exogenous lectin-targeted delivery carriers. It describes vaginal, nasal, oral, ocular, and transdermal drug delivery systems, reviews the interactions between bioadhesives and mucosal tissues in the eye, mouth, respiratory system, urinary system, and gastrointestinal tract, and explores product development, clinical testing, production process issues, and more. About the authors: EDITH MATHIOWITZ, Professor of Medicine and Engineering at Brown University in Providence, Rhode Island, and director of graduate courses in artificial organs, biomaterials, and cellular technology. Has developed over 150 journal articles, abstracts, and briefs as author or co-author. DONALD E. CHICKERING III, Manager of Formulation and Processing Research at Acusphere in Cambridge, Massachusetts. Has published over 25 journal articles, abstracts, and briefs on drug particle technology as author or co-author and holds four patents. Former project manager of Sulzer Carbomedics drug delivery systems in Austin, Texas. Recipient of the American Association for the Advancement of Medical Instrumentation's Young Investigator Award. CLAUS-MICHAEL LEHR, Director of the Department of Biopharmaceutics and Pharmaceutical Technology at Saarland University in Saarbrücken, Germany. Has published over 40 journal articles, reviews, and book chapters as author or co-author and holds three patents. Table of Contents: The book is divided into four main parts: Basic Principles of Bioadhesion; Bioadhesion