Which inflammations can cause an increase in 125?

Patient's question:

I have had gynecological inflammation for a long time. Recently, I went to the hospital for a check-up, and the results showed elevated CA125. I have always suspected whether it is caused by my gynecological inflammation. Does gynecological inflammation lead to elevated CA125?

Doctor's answer:

Gynecological inflammation can lead to elevated CA125 levels, especially when it causes pelvic-related inflammation, making it more likely to occur. During pregnancy, its related indicators may also rise, including alpha-fetoprotein in late pregnancy, which further increases these indicators. CA125 is a glycoprotein produced by the uterus, cervix, fallopian tubes, as well as the inner surfaces of the chest and abdominal cavities. When the tissues of these organs are damaged or inflamed, it can cause elevated blood CA125 levels, which is common in conditions such as endometriosis and ovarian cancer.

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