Specialist Physicians Rational Drug Use - Rational Drug Use for Gastroenterology

Author: Xuan Shiying, Wang Qing, Li Deai (Editor-in-Chief)
Publisher:
Publish Date: 2004-03-01
Features: With the continuous in-depth research and development of science and technology, medical science has also been rapidly advancing. The mechanisms of occurrence for digestive system diseases have been continuously making new breakthroughs, leading to progress in understanding certain diseases. In the pharmacological treatment of digestive system diseases, new theories and methods have emerged. For example, in the late 1980s, proton pump inhibitors were developed, which specifically target the final step of gastric acid secretion—the H+K+-ATPase—thereby enhancing and prolonging the antisecretory effect. This significantly improved the healing of peptic ulcers and reduced the risk of complications. Additionally, further insights have been gained into the mechanism of gastric parietal cell secretion of gastric acid. Similarly, the use of proton pump inhibitors has shown excellent efficacy in the treatment of gastroesophageal reflux disease, making them a key therapeutic agent in the diagnostic and treatment process.
In the pharmaceutical field, the current common method for obtaining a single enantiomer is the resolution of racemates, from which a single enantiomer with a purity of up to 95% can be obtained. However, this resolution process often involves multiple intermediate steps, leading to partial product loss and relatively high costs. The asymmetric catalytic method is now the most important approach for obtaining single enantiomers. In 2001, K. Barry Sharpless, William Knowles, and Ryoji Noyori were awarded the Nobel Prize in Chemistry for their research in this area, which led to the development of "chiral" drugs.
Over the years, medical professionals have studied the occurrence and development of gastrointestinal dysfunction, leading to the development of prokinetic drugs. This has further deepened the understanding of gastrointestinal motility disorders and allowed clinicians to solve previously unexplained issues, making significant progress in recognizing the pathogenic mechanisms and improving clinical efficacy for such diseases. In the treatment of ulcerative colitis, the emergence of 5-aminosalicylic acid has greatly reduced drug side effects. With the rapid development of such therapeutic drugs, medical professionals, especially middle-aged and young ones, face a wide range of medications and need to expand their pharmacological knowledge. Clinicians should clearly understand the potential effects of these drugs when used in the human body. To use medications reasonably in clinical practice and achieve good therapeutic outcomes, medical professionals should master the basic theories of pharmacology, including the pharmacokinetics, mechanisms of action, indications, and adverse reactions of various drugs.
Similarly, pharmacological researchers must also understand the clinical efficacy of drugs. This book is divided into 10 chapters, providing a comprehensive discussion of the main drugs used in the current treatment of common digestive system diseases. It elaborates on the pharmacological effects in detail while objectively commenting on clinical application methods and experiences, aiming to fully reflect the progress of drug treatment for digestive system diseases both domestically and internationally, as well as new theories on disease occurrence. It also compiles clinical experiences from experts, closely integrating theory with practice.
In the final chapter, the book discusses drug metabolism in the liver and important considerations, further enriching its content and striving for completeness. At the beginning of each chapter, there is an overview of the disease to provide a general understanding, enabling better clinical application of medications.