Patient's question:
Weight: 21 jin. At 5 months, the neck is soft and cannot roll over. At 12 months, makes babbling sounds and; At 18 months, can sit and stand with support against a wall but cannot maintain balance for long, poor balance.Checkup Results: Guangzhou Children's Hospital conducted the following tests (initially diagnosed as psychomotor developmental delay)
1. Brain CT (normal scan)
2. Lateral Lumbar Spine X-ray (normal scan)
3. GCMs Analysis (Children):
- First result: Urine contains large amounts of succinate, moderate amounts of pyruvate, lactate, and small amounts of fumarate; please correlate with clinical mitochondrial energy metabolism disorders.
- Second follow-up: Urine shows large amounts of lactate; please correlate with clinical attention to hyperlactatemia.
4. MRI: Bilateral lateral ventricles are prominent; please correlate with clinical analysis.
5. Chromosome Karyotype Analysis: No structural or numerical abnormalities in chromosomes found.
6. Metabolism 1:
- Prealbumin: 186.1 (normal: 400)
- Creatine Kinase: 55 (normal: 0-37)
- Low-Density Lipoprotein: 2.51 (normal: 2.7-3.1)
- B-Oxobutyrate: 0.00 (normal: 1.8)
7. Blood Lactate: 1.8 (normal range: 0.9-1.7) elevated
8. Blood Ammonia: 22 (normal range: 10-471.7) normal
9. Blood Acylcarnitine Analysis: Glutamine and other amino acid levels elevated (due to elevated blood ammonia)
10. Evoked Potential Test: Normal
11. Mitochondrial Encephalomyopathy Gene Test: Tested three mutation sites on mtDNA (A3243G/MELAS, A8344G/MERRF, T8993G/C/LS), no mutations found.
Doctor's answer:
Analysis of the condition:Hello, anxiety is the most common emotional state. For example, if you are about to take an exam and feel like you haven't studied enough, you may feel tense and worried—this is anxiety.
Suggestions:
It is recommended to use medication. Antianxiety drugs are the first-line medications for treating anxiety. The most commonly used drugs for anxiety are benzodiazepines, with diazepam being the most frequently prescribed. Both oryzanol and vitamin B1 are classified as neurotrophic drugs. The combined use of diazepam, oryzanol, and vitamin B1 for treating anxiety can not only improve insomnia and anxiety but also enhance the function of the autonomic nervous system, yielding more significant results.