Patient's question:
Age 29, blood test at 19 weeks and 4 days of pregnancy, weight 58.5kg Screening report: Received the results of the triple test, with a critical risk of trisomy 21. Should I have an amniocentesis or a non-invasive DNA test?Results: AFP 64.71 U/ml, corrected MoM 1.16
hCGb 21.19 g/ml, corrected MoM 2.22
uE3 36.744 mol/L, corrected MoM 0.85
Trisomy 21 risk value: 1:1000 (critical risk)
Trisomy 18 risk value: 1:100,000 (low risk)
NTD (neural tube defect) risk: low risk
Doctor's answer:
Medical Analysis: Hello, whether to proceed is your decision to make. However, it's important to understand these points first. The Down syndrome screening is a probabilistic test: the high-risk group indicates a higher likelihood of the fetus being a Down syndrome child, while there is still a possibility in the low-risk group. A blood screening value greater than 1/270 classifies a person as high-risk, with a normal value around 1/700. The international standard is 1/270. Additionally, the Down syndrome screening value is a corrected value. Factors affecting the Down syndrome screening value mainly include: maternal age, gestational age, fetal alpha-fetoprotein levels, human chorionic gonadotropin (hCG) levels secreted by the placenta, medication factors, genetic factors, etc. Taking "Dolima" for fetal preservation may cause hCG levels to exceed the normal range, potentially affecting the Down syndrome screening value.Medical Advice: Currently, the only medical method to determine if the fetus is a Down syndrome child is through amniocentesis. Amniocentesis involves extracting amniotic fluid, culturing fetal cells that have fallen into the fluid, and examining the chromosomes of these cells (specifically the 21st chromosome of the fetus).
Amniotic fluid extraction: 20ml of amniotic fluid is collected. The risks include potential infection, amniotic fluid leakage, and miscarriage. The probability of miscarriage is 1/1000.