Patient's question:
My girlfriend's mother and my maternal grandfather (my mother's father) are from the same great-grandfather. My girlfriend and I want to do a pre-marital genetic test. What preparations are needed? Our relationship can also be explained as my great-grandfather (my grandfather's father) and my girlfriend's grandfather (her mother's father) being the same father! The common ancestor of my girlfriend and me is the fifth-generation great-grandfather-grandfather-mother-me, and the common ancestor is the grandfather-her mother-her.Doctor's answer:
Hello! You do not belong to consanguineous marriage. Because consanguinity refers to having a common ancestor within 3-4 generations. If they marry each other, it is called consanguineous mating. Couples who engage in consanguineous mating may inherit the same gene from their common ancestor and pass it on to their children. If this gene is inherited in an autosomal recessive manner, their children may develop the disease because of being a homozygous mutant. Therefore, consanguineous mating increases the risk of certain autosomal recessive genetic diseases.Pre-marital examination items: Chromosome testing is to detect genetic diseases such as Klinefelter syndrome and Turner syndrome, as well as infertility at an early stage. So don't worry, and many places are very casual about pre-marital examinations, even just a quick look.