Patient's question:
Close relative marriage and non-close relative marriage!! Are both prone to generational inheritance diseases?? Is diabetes a generational inheritance disease??Doctor's answer:
From a genetic perspective, the transmission of pathogenic genes is passed down from generation to generation. Once an individual does not inherit a specific pathogenic gene from its parents, its descendants generally do not need to worry about the hereditary disease caused by this gene.Guidance: Most children with X-linked hereditary diseases are male. When tracing the family history of these patients, it can be found that their mothers are healthy, but their maternal grandfather is the patient. From this, two characteristics can be summarized: ① X-linked hereditary diseases are passed from maternal grandfather to grandson, skipping the mother's generation, with a clear phenomenon of intergenerational inheritance. Why are these X-linked hereditary diseases inherited intergenerationally? Because this disease is a recessive genetic disease and is transmitted through females. Females do not develop the disease but carry the pathogenic gene for X-linked hereditary diseases and pass it to their male offspring. For example, hemophilia A, its pathogenic gene is a mutation in the eighth coagulation factor on the X chromosome, which is a typical recessive genetic disease, and all affected individuals are male. Since the sex chromosome passed from a father to his son is only Y, and the one passed to his daughter is the only X chromosome carrying the pathogenic gene, therefore, a man with hemophilia will have completely normal sons, while his daughters, although phenotypically normal, are all carriers of the pathogenic gene. When they marry, about half of their sons will suffer from the hereditary disease their maternal grandfather had. Thus, although X-linked recessive hereditary diseases have an intergenerational phenomenon, the pathogenic gene is always passed down through the patient's daughters in life.
Lifestyle care: Diabetes is related to genetic factors. If both parents are diabetic, the chance of their children developing diabetes significantly increases. After decades of research, it has been consistently agreed that diabetes is a complex syndrome with multiple causes. Because the incidence of diabetes in relatives of diabetic patients is higher than that in relatives of non-diabetic patients, it indicates that diabetes has a genetic tendency. The inheritance of diabetes is not the disease itself but the susceptibility to diabetes, which requires certain environmental factors to develop into diabetes.