Patient's question:
I and my wife are both in good health, but my wife mentioned before that her mother has some genetic diseases caused by chromosomal abnormalities. I feel sad that my wife might also develop this genetic disease again. Which people are prone to chromosomal abnormalities?Doctor's answer:
Normal humans have 46 chromosomes. The karyotype of a normal male should be 46XY. The karyotype of a normal female should be 46XX. If your chromosomes do not match these results, it is abnormal. Chromosomal abnormalities are divided into numerical abnormalities and structural abnormalities. Numerical chromosomal abnormalities include polyploidy (e.g., 96 chromosomes), haploidy (23 chromosomes), mosaicism (e.g., 46XX/45XO), and simple numerical abnormalities, such as trisomy 21, 45-XO, 47XXY, etc.