What is the meaning of chromosomal abnormalities?

Patient's question:

I am 26 years old, and I have had two miscarriages. After a thorough examination, the doctor said I have a chromosomal abnormality. I would like to consult about what chromosomal abnormality means?

Doctor's answer:

Chromosomes are the fundamental substances composed in the nucleus of human cells, serving as carriers of genes. Humans have 46 chromosomes (23 pairs). Abnormalities in chromosomes can be divided into numerical abnormalities and structural abnormalities. For example, the most common Down syndrome (trisomy 21) is a numerical abnormality. The cause of chromosomal is currently unclear, possibly originating from the mother or due to the reoccurrence of non-fusion of chromosomes during the late stage of cell division, or the fragmentation and reunion of chromosomes under various internal and external factors.

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