What blood type can cause hemolytic disease?

Patient's question:

What blood type can lead to recurrent hemolysis? If both spouses are Type O blood, how can hemolysis recur?

Doctor's answer:

Hemolysis is equivalent to a war. When different blood types mix, it's like two armies clashing. Conflict leads to casualties, and when two different blood types clash, red blood cells are again destroyed and, which once again triggers hemolysis. When hemolysis occurs again, symptoms such as fever and jaundice often accompany it. When a mother and child have incompatible blood types, neonatal hemolysis often occurs. Any blood type can experience hemolysis. If both parents are Type O blood, neonatal hemolysis will never occur.

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