What is the cause of systemic lupus erythematosus?

Patient's question:

I am 53 years old. Recently, as I have gotten older, I have been experiencing leg pain. I have previously visited the immunology department, but the effect was not significant. I have taken both Chinese and Western medicine, especially when the weather changes, I feel uncomfortable. What are the causes of systemic lupus erythematosus?

Doctor's answer:

Systemic lupus erythematosus is primarily associated with intergenerational inheritance. Moreover, it is a polygenic related disease. Because multiple genes interact under certain conditions or environments, leading to altered normal immune tolerance and hemophagocytic disease. Some environmental factors, such as ultraviolet rays, certain drugs and chemicals, and microorganisms, etc. In clinical diagnosis, the incidence of systemic lupus erythematosus in women is significantly lower than in men, so it should also be related to estrogen.

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