Patient's question:
A few days ago, I noticed that my husband's complexion was not normal. Besides a slight yellowish tint, his lips were pale, and when I lifted his tongue, I found that it was slightly purple. He used to have chronic hepatitis B with a high viral load (HBeAg positive), but now it has turned into a low viral load (HBeAg negative). Is this symptom indicating that he is getting better?Doctor's answer:
The transformation from hepatitis B "big three positive" to "small two positive" is essentially due to the virus count being reduced, allowing the pathogen to be controlled without excessive replication. This is a standard indicator of effective clinical diagnosis and treatment. From a clinical diagnostic perspective, the hepatitis B "big three positive" condition has been controlled, but it does not necessarily mean that the hepatitis B disease has improved. Symptoms can gradually recover, meaning that the "big three positive" condition causes liver damage, while the "small two positive" condition generally has a low virus count, and the liver will not be damaged.