Patient's question:
Does polycystic kidney disease be inherited across generations? My grandmother has kidney disease, will it be inherited to my grandson across generations? The child is still young, and it hasn't been discovered yet, but I'm a bit worried because it's said that this disease can be inherited across generations. So I want to consult a few things. What should be paid attention to in daily life? Probability of polycystic kidney disease being inherited across generations?Doctor's answer:
Regarding the hereditary probability of polycystic kidney disease across generations, polycystic kidney disease is named for the presence of numerous thin-walled spherical cysts in both the renal cortex and medulla, and it is an autosomal dominant genetic disorder. The incidence of polycystic kidney disease shows no significant difference between males and females. The most common symptoms include flank pain, hematuria, and nocturia. Approximately 10% of patients have kidney stones, and some may experience renal colic due to stones and blood clots causing intestinal obstruction. Most patients will develop second-degree urinary tract infections. The cysts may be surrounded by normal renal parenchyma or may be associated with chronic interstitial nephritis. The inflammation is often bilateral, with unilateral cases accounting for only 10%. As the cysts encroach on renal units, they cause localized intrarenal obstruction, impairing renal function and often leading to gradual kidney failure, accounting for 5% to 10% of causes of uremia.