How does uremia eventually lead to death?

Patient's question:

Creatinine 809, the doctor asked my friend to do dialysis. What should my friend do? My friend doesn't want to do dialysis. Why is that? Currently, besides urine output, the cause of my friend's illness is unclear. Hello, how does uremia eventually lead to death?

Doctor's answer:

When uremia progresses beyond the end-stage, heart failure is a severe complication and the leading cause of death in uremic patients. Among patients undergoing maintenance hemodialysis, the incidence of congestive heart failure exceeds 41%-50%, with a mortality rate reaching 40%. Therefore, actively and effectively controlling heart failure can reduce the risk of death in uremic patients, lower quality of life, and shorten lifespan. Thus, it is essential to fulfill one's wishes and maintain a positive mindset.

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