Asymmetric catalysis on an industrial scale

Author: Brase
Publisher:
Publish Date: 2006-09-01
Features: This book elaborates on the work of chemical and biocatalysis in asymmetric organic synthesis reactions at industrial scale, organized by various methods and products. The content includes asymmetric hydrogenation and reduction reactions and their applications in L-dopa, isopropyl methylcarbamate, α-tocopherol, 2-hydroxy-4-phenylbutyric acid, etc.; biocatalytic production processes of numerous asymmetric synthons; chemical and enzymatic catalytic production processes of 7-aminocephalosporanic acid; enzymatic catalytic production processes of cyanohydrins such as L-amino acids and mandelic acid; hydrolysis kinetics of epichlorohydrin; chemical and biocatalytic processes in asymmetric transfer hydrogenation and oxidation reactions for the production of important pharmaceutical intermediates (e.g., chiral alcohols, chloroalcohols, amines, (sulfonic acid) esters, hydroxy acids, cyclopropanecarboxylic acids, sulfides) and various non-natural amino acids and biotin. The book introduces the journey and experience of researchers in transforming laboratory work into truly useful production processes. This book is a unique and highly specialized monograph on the development of chemical product processes. The valuable and authoritative insights presented, both positive and negative, serve as a reference for researchers working in the fields of chemistry, chemical engineering, biology, catalysis, and pharmaceuticals in chemical product development and research. It is also a reference book for students and faculty in related disciplines at universities and colleges to learn practical experience.