Introduction to the Interaction of Organizations and Biomaterials

Author: Dee (USA) and others
Publisher:
Publish Date: 2005-01-01
Features: The interaction between tissues and biomaterials is considered the core issue of human disease or the creation of tissue organ substitutes. The microscopic and tissue-level responses of hip replacement implants, dental implants, pacemaker leads, cardiovascular grafts, heart valves, and dialysis devices determine the success or failure of these devices. The purpose of Introduction to Tissue-Biomaterial Interactions is to familiarize college students with this complex and highly important fundamental biological process. Chapters 1 to 2 elaborate on the molecular-level phenomena at the tissue-implant interface, while Chapters 4 to 10 reveal the impact of these phenomena on the biological and physiological effects of selected materials. The book emphasizes the importance of the human body's wound healing response. Key issues include: the structure and properties of biomaterials, proteins, protein-surface interactions, blood-biomaterial interactions, inflammation and infection, the immune system, the response of biomaterials to implantation, biomaterial surface engineering, and intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions. The book also introduces important concepts related to three interfaces—human-biomaterial, human-implant with living cells, and cell-biomaterial—which are significant for tissue engineering products containing living cells in implants. This book is suitable for a one-semester course in biomedical engineering. Introduction to Tissue-Biomaterial Interactions provides a foundation for understanding biomedical implants of today and tomorrow. The interaction between human tissues and artificial materials is the core issue of human disease or traumatic tissue organ replacement. The mechanisms and responses at the molecular, cellular, and tissue levels of the tissue-implant interface with hip replacement implants, dental implants, pacemaker leads, cardiovascular grafts, heart valves, and dialysis devices determine the success or failure of these devices. The purpose of Introduction to Tissue-Biomaterial Interactions is to familiarize readers with this complex and highly important biological process. Chapters 1 to 3 provide details on the molecular-level phenomena at the tissue-implant interface, while Chapters 4 to 10 elaborate on the impact of these phenomena on selected materials, biology, and physiology. The book emphasizes the importance of the human wound healing response and comprehensively introduces issues such as the structure and properties of biomaterials, protein-surface interactions, blood-surface interactions, inflammation and infection, the immune system, the response of biomaterials to implantation, and biomaterial surface engineering, along with multiple examples of tissue-biomaterial interactions. The book also introduces important concepts related to three interfaces—human-biomaterial, human-implant with living cells, and cell-biomaterial—which are significant for tissue engineering products containing living cells in implants. This book provides valuable reference materials for researchers and students in the field of biomedical engineering, offering a foundation for understanding and studying biomedical implants of today and tomorrow.