Patient's question:
Detailed medical condition and consultation purpose: Doctor: Hello, my test report shows:Liquefaction time: Non-liquefiable
Volume: 2
Color: Grey-white
pH: 7.5
Sperm density: 80
Motility rate: 75
Grade B: 40
Grade C: 35
Grade D: 25
Please ask what kind of disease this belongs to. How should it be treated?
Doctor's answer:
Hello, normal semen is in a liquid state when expelled but quickly solidifies into a gel-like or clotted state. It liquefies into a watery liquid within about 10 to 20 minutes. This process is called semen liquefaction and is a normal physiological phenomenon. If semen remains in a gel-like state for more than 30 minutes after ejaculation, it is considered a pathological condition known as semen non-liquefaction. The initial liquid state of semen facilitates ejaculation, while its transformation into a gel-like state helps it stay in the female vagina without easily flowing out. Subsequently, liquefaction allows sperm in the semen to move freely, enabling them to swim along the female reproductive tract toward the fallopian tubes, which facilitates fertilization of the egg.The gel-like consistency of semen is caused by coagulating proteins secreted by the seminal vesicles. In contrast, proteolytic enzymes and fibrinolysin secreted by the prostate can break down this coagulating protein, promoting semen liquefaction. Therefore, semen non-liquefaction is caused by an excess of coagulating proteins or a deficiency of proteolytic enzymes and fibrinolysin. During semen analysis, if the semen appears non-coagulated, it may be due to defects in the ejaculatory ducts or congenital absence of the seminal vesicles.
Non-liquefied semen, when observed under a microscope, shows sperm clumped together, unable to move or only slowly twitching. Such semen severely hinders sperm movement within the female reproductive tract, preventing them from ascending into the cervical canal, uterine cavity, or fallopian tubes, where they cannot encounter the egg. As a result, it fails to fertilize the female.
Common causes of semen non-liquefaction include seminal vesiculitis and prostatitis, leading to