What does a negative newborn disease screening result mean?

Patient's question:

The results of the newborn disease screening have come out. The doctor didn't say anything, and I saw that the report shows negative. What does this mean?

Doctor's answer:

The negative results of newborn screening have the following meanings:
1. No related diseases were found;
2. The sensitivity of the detection method is approximately 95%, and no detection method can achieve 100%, with a 5% possibility of false negatives.
3. Other influencing factors, such as improper blood collection timing (too early or too late), affect the screening results;
4. Interferences from newborns not consuming milk or having diseases;
5. Improper specimen storage during screening, specimen damage, or repeated dripping of blood during blood collection.

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