Patient's question:
Diagnosed with premature ovarian failure, amenorrhea, FSH 66, LH 41, E2 213. Took some Chinese medicine intermittently, but the effect was not very good.Doctor's answer:
Estrogen-progestogen replacement therapy is very important for young women with premature ovarian failure (POF). It can alleviate low estrogen symptoms and urogenital atrophy (preparing for oocyte donation embryo transfer) while also preventing long-term complications (such as osteoporosis, Alzheimer's disease, etc.) and reducing the risk of colorectal cancer by 37%. However, long-term HRT also carries certain risks, such as the development of endometrial cancer and breast cancer. But studies have shown that estrogen-progestogen replacement therapy with monthly progestogen use exceeding 10 days can reduce the risk of endometrial cancer to nearly zero, while the risk of breast cancer slightly increases, but mortality does not rise. A sequential combination of estrogen and progestogen is typically used. Before starting HRT, a personalized weighing of benefits and risks should be conducted, along with necessary monitoring and follow-up.