Patient's question:
NoDoctor's answer:
From the perspective of drug efficacy and action, the use of progesterone can relax uterine muscles and reduce the responsiveness of the pregnant uterus to external stimuli, which is beneficial for the growth and development of the fertilized egg within the uterus. It is only suitable for threatened miscarriage and habitual abortion caused by luteal function deficiency. However, it should be noted that using progesterone for fetal preservation without endocrine testing is ineffective and may even have the opposite effect. Recent studies have found that, on one hand, progesterone can lead to fetal developmental deformities, particularly in male fetuses. Early use of this medication can affect fetal gonadal development and result in abnormal external genitalia. On the other hand, it can also inhibit uterine contractions, weakening the pregnant woman's natural ability to have a complete miscarriage, which may lead to prolonged retention of a dead fetus, known as "" (prolonged missed miscarriage). Therefore, most experts both domestically and internationally no longer advocate for the use of progesterone for fetal preservation.