Patient's question:
What are the hazards of immunological infertility? Please introduce it.Doctor's answer:
The hazards of immunological infertility mainly include:1. Blocking the zona pellucida recognition sites on the acrosomal membrane, inhibiting sperm attachment and penetration into the zona pellucida.
2. Affecting the normal activity of sperm enzymes, impairing the dispersion of the zona pellucida and corona radiata. Moreover, sperm antibodies primarily inhibit the activity of hyaluronidase, thereby interfering with sperm dispersion.
3. Impairing embryo development. Factors or causes leading to immunological infertility are diverse. Any condition that disrupts the blood-testis barrier, causes accessory gland infection, exposes the testes to high temperatures, or induces injury, resulting in the formation of sperm antibodies, will contribute to immunological infertility.
4. Preventing sperm from penetrating cervical mucus. Sperm antibodies typically cause sperm to clump together, hindering their motility. Additionally, sperm immobilization antibodies exhibit cytotoxic effects, leading to sperm death or impairing their movement. They may also block the zona pellucida recognition sites on the acrosomal membrane, affecting sperm attachment and penetration into the zona pellucida.