Patient's question:
My wife has been married for 4 years without pregnancy. After detailed examinations from multiple sources (menstrual cycle, uterine shape, fallopian tube, endocrine hormone levels, anti-sperm antibodies, etc., all normal), only the ultrasound monitoring showed no ovulation (there were dominant follicles, but they did not rupture and shrank by the time of ovulation). After half a year of treatment with (clomiphene + progesterone injections), it was ineffective. I am very distressed. How should it be treated?Doctor's answer:
Hello: Under normal circumstances, an egg follicle developing to a size of 1.8-2.5 cm falls within the normal range. I wonder at what stage your egg follicle has developed? Egg follicles disappear after reaching a certain size, a medical condition known as Luteinized Unruptured Follicle Syndrome (LUFS): It refers to a group of symptoms characterized by regular menstrual cycles and the assumption of ovulation, but in reality, the follicle does not rupture during the mid-cycle, leading to no ovulation. It is one of the important factors or causes of infertility. Patients are often clinically diagnosed with unexplained infertility, luteal phase deficiency, endometriosis, or pelvic inflammatory disease. In cases where patients with ovulation dysfunction experience "successful ovulation" but still fail to conceive, this condition should also be considered. In addition to the symptoms of the aforementioned diseases, patients may have no other symptoms. During examinations, a regular menstrual cycle and biphasic basal body temperature can be observed; premenstrual diagnostic curettage may show secretory changes in the endometrium; after the rise in basal body temperature, estrogen and progesterone levels may remain within the normal range. Our hospital is a specialized institution for treating infertility. We recommend that you come to our hospital for examination to identify the cause and receive targeted treatment.