Patient's question:
How can someone get this disease? What exactly causes metrorrhagia?Doctor's answer:
Dysfunctional uterine bleeding (DUB), also known as functional disorders of uterine bleeding, primarily refers to abnormal uterine bleeding caused by dysregulation of the neuroendocrine mechanisms that regulate reproduction. It is divided into two types: ovulatory bleeding and anovulatory bleeding. The main factors or causes of DUB include:1. Systemic factors: These include adverse psychological trauma, stress, malnutrition, endocrine and metabolic disorders such as iron deficiency, anemia, aplastic anemia, blood diseases, bleeding disorders, diabetes, thyroid disorders, and adrenal gland diseases.
2. HPO axis dysfunction: This includes irregular rhythms in the release of reproductive hormones, impaired feedback mechanisms, ovulatory dysfunction, and luteal dysfunction.
3. Uterine and endometrial factors: These include abnormalities in the structure and function of spiral arteries, microcirculatory vascular beds, steroid receptor dysfunction, lysosomal dysfunction, abnormal local coagulation mechanisms, and dysregulation of prostaglandin TXA2 and PGI2 secretion.
4. Iatrogenic factors: These include the use of steroid contraceptives and intrauterine devices (IUDs) that interfere with normal HPO axis function. Certain medications for systemic diseases (especially those affecting the nervous system) can influence normal menstrual function through neuroendocrine mechanisms.
Since this lady is unaware of your specific clinical presentation, it is recommended that if you have the opportunity, you should undergo hormone level testing at the hospital. If there is bleeding, a diagnostic curettage or laboratory tests such as a complete blood count (CBC), platelet count, and bleeding/coagulation time may be performed to determine the degree of anemia and whether there are any blood disorders. All of these can aid in the diagnosis of the condition.
Gansu Renai Obstetrics and Gynecology Hospital reminds you: If patients with this condition have ovulatory dysfunction, menstrual irregularities, or excessive bleeding, they may also develop organic lesions. Therefore, it is recommended that you seek early diagnosis and active treatment if you have the opportunity.