Patient's question:
How have I had three natural miscarriages in these three years. The check shows I have antisperm antibodiesDoctor's answer:
1. Blocking sperm from penetrating cervical mucus, antisperm antibodies can cause sperm to clump together, hindering sperm motility. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or affecting sperm motility. Additionally, they may also have some impact on sperm metabolism and the function of sperm contraction proteins.2. Affecting the activity of sperm enzymes, inhibiting the dispersing function of the zona pellucida and corona radiata, including:
① Acrosin: Promotes sperm penetration through the zona pellucida and facilitates sperm-egg fusion;
② Sperm hyaluronidase: Disperses the cumulus oophorus (corona radiata). Sperm antibodies primarily inhibit the activity of hyaluronidase, disrupting the dispersing function of sperm.