Patient's question:
Hello doctor, I would like to consult about what causes semen to fail to liquefy. My friend got married a year later than me, but now their child is already 2 years old, and we haven't been able to conceive yet. Yesterday, when I went for a checkup, the doctor said it was an issue with my husband's sperm not liquefying. Does this significantly affect fertility? What are the reasons for semen not liquefying?Doctor's answer:
1. Mycoplasma, Chlamydia trachomatis, and Neisseria gonorrhoeae infection: If a patient is infected with mycoplasma, it can lead to dysfunction of the accessory glands, causing direct changes in the composition of semen, resulting in semen not liquefying and thus affecting fertility.2. Prostate diseases: Prostate diseases can cause patients to experience semen liquefaction issues. Experts explain that the liquefaction and coagulation of semen are regulated by coagulating proteins and liquefying factors in the semen. As enzymes that function as liquefying factors, when prostate secretion activity decreases, their activity weakens continuously, leading to semen liquefaction problems in patients.
3. Idiopathic non-liquefaction syndrome: Some patients with non-liquefiable semen may also suffer from idiopathic non-liquefaction syndrome, which has very poor outcomes in clinical treatment.