Is the possibility of genetic inheritance across generations high in cases of close-kin marriage?

Patient's question:

Hello, I have a question to ask. My husband's parents are first cousins, which means they are close relatives who married. All three of my husband's sisters are perfectly normal. Could our child have certain genetic diseases? How can we prevent this? Is it likely to be inherited from the previous generation?

Doctor's answer:

According to what you mentioned, in general, the possibility of intergenerational inheritance is relatively rare. In the case you described, both conditions should be considered problematic, as they are both hereditary diseases. Therefore, if both conditions test positive, further diagnosis should be conducted, and in necessary cases, pregnancy should be terminated.

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