Patient's question:
[Condition Description: My grandmother and her grandmother are the same biological mother, we are three generations, will marriage be affected? Past treatment history and effectiveness: My grandmother and her grandmother are the same biological mother, we are three generations, will marriage be affected? What kind of help do you want: My grandmother and her grandmother are the same biological mother, we are three generations, will marriage be affected?]Doctor's answer:
It refers to having common blood relations within three generations or closer. If they marry each other, it is called consanguineous marriage. They share too many similar genetic factors, and offspring cannot produce variation from them. Harmful genes will be passed on to descendants.If this gene is inherited in an autosomal recessive manner, their children may develop the disease because they are homozygous for the mutation. Therefore, consanguineous marriage increases the risk of certain autosomal recessive genetic diseases. Consanguineous marriage increases the probability that offspring will inherit a pair of homozygous or identical genes. This correlation coefficient is called the inbreeding coefficient (inbreeding coefficient, IF).