Patient's question:
Hello, my brother is preparing for a blind date. I heard that the girl's grandmother and grandfather are first cousins, and her mother has severe disabilities. I don't know if marrying a girl in this situation would have any adverse effects on future generations. I am very anxious. I look forward to!!! Thank you!!!Doctor's answer:
Cousin couples may inherit the same gene from their common ancestors and pass it on to their children. If this gene is inherited in an autosomal recessive manner, their children may develop the disease because they are homozygous for the mutation.If the offspring of consanguineous marriage do not have a clear family or personal genetic history, they should not worry about the consequences of consanguineous marriage when marrying a non-consanguineous partner. In other words, the impact on offspring is no different from that of normal marriage.