Patient's question:
I got my IUD removed last month, and it was around the time of my period. This month, my period lasted for two weeks, which is unusual for me as my periods are usually normal. The hospital said I was pregnant and had a miscarriage. I want to know what could have caused the miscarriage?Doctor's answer:
1. Chromosomal abnormalities. Chromosomal abnormalities include numerical abnormalities, such as monosomy, trisomy, and polyploidy; structural abnormalities, such as breaks, deletions, and translocations, can all cause miscarriage.2. Endocrine disorders. Excessive estrogen and insufficient progesterone are also causes of early miscarriage. During the 12th to 14th weeks of pregnancy, when the placenta is forming to replace the corpus luteum's function, endocrine disorders are more likely, especially luteal phase deficiency. Additionally, a lack of thyroxine impairs cellular oxidative processes, and conditions such as hyperthyroidism and diabetes can also increase the risk of miscarriage.
3. Placental abnormalities and insufficient placental endocrine function. Decidualitis during early pregnancy can cause bleeding or hyperplasia in the basal decidua, dissolution of trophoblast and decidual cells, and obstruction of blood vessels within the villi, affecting the absorption and transport of nutrients. This may lead to the separation of the embryo from its attachment site, resulting in bleeding and miscarriage. Furthermore, large placental infarctions can reduce placental function and threaten fetal survival; conditions such as placenta previa and edematous degeneration of placental villi are also common causes of miscarriage. If β-hCG, hPL, P, E2, and estriol levels in maternal blood decline during early pregnancy, the risk of miscarriage is 50%.