Patient's question:
I previously had two sons with Hemophilia A, and now I am four months pregnant with my second husband. How can I screen to see if this child might also have the disease? There is no generational family history.Doctor's answer:
Hemophilia is a recessive genetic disease on the X chromosome, so women are usually carriers, while men are more prone to the disease, which is expressed as transmission from female to male. For example, if a male hemophiliac marries a normal woman, their daughters will definitely be carriers, while their sons will definitely not have the disease. If a carrier woman marries a normal man, there is a 50% chance that their sons may be affected and a 50% chance that they may be normal. Their daughters also have a 50% chance of being normal and a 50% chance of being carriers.