What factors lead to immunological infertility?

Patient's question:

I met my husband when I was in college, and we never took any contraceptive measures while dating. However, I have never been pregnant. Now that we are preparing to get married, my family elders keep urging me, which is really annoying. Please ask: What factors can lead to immunological infertility?

Doctor's answer:

Hello, immunological infertility refers to infertility caused by immunological factors. Immunological infertility accounts for approximately 10-30% of infertility cases, including various types such as antisperm antibodies, anti-endometrial antibodies, anti-ovum antibodies, and other immunological infertility. In clinical diagnosis, the most common type is immunological infertility caused by the production of antisperm antibodies. Due to inflammation in the female reproductive tract, local secretion increases, allowing autoimmune cells to enter the reproductive tract. At the same time, changes in the permeability of the reproductive tract mucosa enhance the absorption of sperm antigens.

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