Patient's question:
After one year of marriage, the couple had always wanted a child, but they never succeeded. After a thorough examination at the hospital, they found out they had immunological infertility. I want to know what the harm of immunological infertility is?Doctor's answer:
Hello, the harms of immunological infertility are as follows:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm immobilization antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm motility. Additionally, they may disrupt sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the aggregation function of the zona pellucida and corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the aggregation of the corona radiata. Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm aggregation.
3. Interfering with embryonic growth and development. There are many different causes of autoimmune infertility.