Genome and Molecular Neuro-Oncology

Author: Zhang Wei
Publisher:
Publish Date: 2005-05-01
Features: This book introduces the rapidly evolving technologies in genomics and molecular biology, and elucidates their capabilities and potential. Each chapter reviews a specific area of molecular neuro-oncology and includes recent applications in diagnosis and research. It covers important technical areas such as genomic instability analysis, methods for studying tumor angiogenesis and invasion, animal models, gene expression profiling, tissue microarray technology, mRNA splicing, functional genomics, and bioinformatics techniques necessary to make the vast amounts of data obtained practical. The book also introduces the widespread applications of these research findings, including the use of genomics and molecular biology techniques to facilitate clinical diagnosis, the identification, validation, and confirmation of new tumor markers or therapeutic targets, the discovery of genes and subsequent studies on related physiological pathways and accompanying biology, as well as the emerging use of molecular biology methods for the classification of brain tumors. This natural symbiotic relationship between fundamental knowledge progress and clinical translation and therapeutic applications constitutes the basic theme of each chapter. This work is highly suitable for neurosurgeons, neuro-oncologists, graduate students, Ph.D. students, postdoctoral researchers, and others in the fields of neurosurgery, neuro-oncology, and related disciplines.