Protein chip

Author: Xie Na
Publisher:
Publish Date: 2005-04-01
Features: With the completion of large-scale sequencing of the human genome, the post-genomic era, primarily focused on functional genomics and proteomics, has arrived. As a highly efficient tool for detecting the presence and dynamic changes of proteins, protein chips will bring about a revolution in fields such as disease diagnosis and treatment, drug development, molecular biology, aerospace, forensic identification, food hygiene, and environmental monitoring in this century. Biochip technology is a high-throughput detection technique that includes three major areas: gene chips, protein chips, and chip-based experiments. Protein chips replace DNA as the target for detection, making them closer to the material level of life activities. They directly measure the relative levels of proteins and their interactions with other molecules, quantifying gene activity to reflect the dynamics of gene expression. As a result, protein chips offer more direct application prospects than gene chips. This book provides a comprehensive and detailed exposition of protein chip technology, covering technical principles, production methods, surface chemistry, detection strategies, and antigen/antibody data analysis. The book is richly illustrated with numerous biological application examples and experimental protocols. It is a comprehensive and informative resource, combining fundamental knowledge and cutting-edge research in protein chip technology. The book is highly practical and easy to read, making it suitable for teaching and research personnel or technicians engaged in biochip research and development, as well as those in related fields such as bioinformatics, proteomics, genomics, molecular biology, biochemistry, cell biology, and biotechnology. It can also serve as a graduate-level textbook.