Asymmetric organic reaction

Author: Li Yue Ming
Publisher:
Publish Date: 2005-01-01
Features: The book is divided into 29 chapters. First is the Nobel Lecture by Dr. Knowles, Professor Noyori, and Professor Sharpless, the 2001 Nobel Prize in Chemistry laureates. It is hoped that readers can grasp some of the essence of asymmetric synthesis/catalysis research from the speeches of these masters. The chapter "Combinatorial Asymmetric Catalysis" summarizes the application of combinatorial chemistry principles in chiral ligand screening and the rapid determination of enantiomeric compositions of chiral compounds, laying a solid foundation for high-throughput screening of chiral ligands. The following chapters (5–7) focus on the application of asymmetric catalytic technology in stereoselective catalytic hydrogenation reactions. Through these chapters, readers can learn about the latest developments in asymmetric catalytic hydrogenation reactions and the design concepts of efficient chiral ligands. The subsequent chapters (8–20) introduce various asymmetric C—C bond formation reactions. It is hoped that readers will gain a fresh understanding of asymmetric C—C bond formation through these chapters and will be able to apply the methods presented to asymmetric synthesis reactions of organic compounds. Chapter 21 introduces asymmetric epoxidation reactions and asymmetric dynamic resolution; Chapter 22 discusses the application of chiral auxiliaries in asymmetric synthesis; Chapter 23 provides an overview and prospects of molecular simulation studies in biofunctional systems; Chapter 24 covers the asymmetric synthesis of natural products. Through these chapters, readers can understand the specific applications of asymmetric catalysis/synthesis. Chapters 25–29 summarize environmentally friendly asymmetric catalytic reactions and the application of recyclable catalysts in asymmetric synthesis. The target readers of this book are graduate students, teachers, and researchers engaged in asymmetric organic reaction research, as well as technical personnel in the pharmaceutical industry, fine chemical industry, and related fields.