Okay, here is the translation following your instructions: Alzheimer's (ALZHEIMER) Dementia Pathogenesis: ABC Hypothesis

Author: Li Wenbin
Publisher:
Publish Date: 2005-01-01
Features: This is a highly specialized academic monograph on the pathogenesis of Alzheimer's disease. The author is a basic and clinical scientist engaged in this research topic. The author uses the three English letters A, B, and C to represent the factors related to the three major pathological and physiological changes of dementia—brain aging, amyloid-beta, and neurotransmitter receptor channels—and their roles in the onset of dementia. The author expresses their views on the causes and mechanisms of Alzheimer's disease: brain aging is the foundation, background, and condition for the onset of dementia; Aβ is the key damaging factor in dementia onset; oxidative stress is the initiating factor of brain aging; free radicals, when combined with or complementary to Aβ, preferentially damage neurotransmitter receptors, leading to imbalances in brain neural circuits, disrupting the integration of neural and psychological functions, and causing the disease. The features of this monograph are: , the academic viewpoints expressed by the author are the scientific summary of their 20 years of research in this field, based on the processing and organization of a large amount of systematic experimental data; second, the content of this monograph aligns with the forefront and mainstream of contemporary scientific development and demonstrates unique insights or new discoveries in certain aspects; third, it is highly practical, providing valuable academic insights and research platforms for the development of aging neurobiology; fourth, this monograph is self-contained, incorporating achievements from multiple disciplines and technical methods, conducting multi-level experimental research, and comprehensively summarizing the characteristic rational thinking process and operational model of scientific research. Therefore, this monograph serves as a reference for basic and clinical scientists in the fields of neurology and psychiatry, as well as a specialized reading material for researchers in this field.