Is the risk rate of Down syndrome 1/323 normal?

Patient's question:

I want to know if a free-hCG level of 4.65 during the Down syndrome screening is very serious.

Doctor's answer:

Analysis of the condition: Hello, Down syndrome is also known as trisomy 21 syndrome. It is a chromosomal abnormality that causes congenital mental retardation, and the rate of intellectual disability after birth is very high. Suggestions: Amniocentesis is the most effective method for fetal anomaly screening. If it is confirmed to be Down syndrome, this condition is not recommended for you.

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