Pregnancy at four months, results of the Down syndrome screening, risk rate of Down syndrome 1

Patient's question:

Okay, here is the translation following your instructions:
Four months pregnant, results of the Down syndrome screening: Down syndrome risk rate 1:223, 18 trisomy syndrome risk rate 1:125000 is there a problem?

Doctor's answer:

According to your condition, there will be certain harm. It is recommended to start medication treatment immediately. Thank you.