Patient's question:
I previously had two pregnancies where the embryos stopped developing. The first time, there was a heartbeat, but the second time, there was no heartbeat or fetal pole. My husband and I have undergone blood tests, antibody tests, and karyotype analysis. My husband has a small Y chromosome (22q11.2 deletion), and his sperm vitality rate is 59%.Could you please advise whether my husband's small Y chromosome is the cause of the embryonic arrest? In this situation, will we still be able to have children in the future?
Doctor's answer:
There are many reasons that can cause embryonic arrest (1) Reproductive endocrine factors, estrogen, progesterone, and chorionic gonadotropin. If the mother's endogenous hormones are insufficient, it can lead to embryonic arrest. (2) Reproductive immune issues. If the body has certain antibodies, it can affect the development of the embryo. (3) Uterine problems. Poor uterine environment or malformations can also cause embryonic arrest. (4) Chromosomal issues. If testing is conducted, it should focus on these four aspects, and both partners should be tested. It is recommended that you seek a diagnosis and treatment at a formal specialized hospital. Wishing you a happy pregnancy!