Patient's question:
My partner had in vitro fertilization, and after the transfer, the doctor at the hospital asked me to take aspirin for the first half month. They told me to continue taking it until the 14th day when I found out I was pregnant. Will this affect the baby?Doctor's answer:
Hello, the above may affect child development.■ Summary: 12-year-old children may cause Reye's syndrome, hyperuricemia, and long-term use can cause liver damage. Pregnant women should avoid use. Alcohol consumers taking therapeutic doses of aspirin may cause spontaneous anterior chamber hemorrhage, so aspirin is not suitable for patients with traumatic anterior chamber hemorrhage. Cesarean section or abortion patients should not use aspirin; aspirin can worsen hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency; newborns, young children, and the elderly seem particularly sensitive to the bleeding effects of aspirin. Therapeutic doses can cause metabolic acidosis, fever, hyperventilation, and central nervous system symptoms in children under 2 years of age.
■ Cross-allergic reactions. If allergic to this product, you may also be allergic to another salicylate drug. However, those allergic to this product may not necessarily be allergic to non-acetylated salicylates.
■ This product can easily pass through the placenta. Animal studies have shown that the use of this product in the first three months of pregnancy can cause teratogenesis, such as spina bifida, cranial fissure, facial fissure, leg malformation, and incomplete development of the central nervous system, internal organs, and bones. There have also been reports of fetal defects in humans after using this product. In addition, long-term and high-dose use of this product in the third trimester of pregnancy can prolong pregnancy and increase the risk of post-term syndrome and antepartum hemorrhage. Use in the last two weeks of pregnancy can increase the risk of fetal or neonatal bleeding. Long-term use in the late stages of pregnancy may also cause fetal arterial duct constriction or early closure, leading to persistent pulmonary hypertension and heart failure in newborns. There have been reports of an increased incidence of stillbirth or neonatal death in the late stages of pregnancy due to excessive use or abuse (possibly due to arterial duct closure, antepartum hemorrhage, or low birth weight), but no such side effects have been observed with general therapeutic doses.
■ This product can be excreted in milk. Breastfeeding women taking 650mg orally can reach a drug concentration of 173–483 μg/ml in milk 5–8 hours later, so long-term and high-dose use may cause adverse reactions in infants.
■ Elderly patients are prone to toxic reactions when taking this product.
■ Children, especially those with fever and dehydration, are prone to toxic reactions. Acute febrile diseases, especially influenza and chickenpox in children, may be associated with the occurrence of Reye's syndrome (Reye’s syndrome), which is still relatively rare in China.
■ The following conditions should be contraindicated:
① Peptic ulcer with bleeding symptoms or other active bleeding;
② Hemophilia or thrombocytopenia;
② Peptic ulcer or corrosive gastritis;
③ Glucose-6-phosphate dehydrogenase deficiency (this product occasionally causes hemolytic anemia);
④ Gout (this product can affect the action of other uric acid excretion drugs, and may cause uric acid retention at low doses);
⑤ Liver function impairment can exacerbate liver toxicity and bleeding tendency, and patients with liver dysfunction and cirrhosis are prone to kidney adverse reactions;
⑥ Heart failure or hypertension, large doses may cause heart failure or pulmonary edema;
⑦ Renal failure may increase the risk of kidney toxicity.
■ The following conditions should be used with caution:
① Asthma and other allergic reactions.