Can individuals with RH negative blood have a second child?

Patient's question:

My wife is Rh-negative blood. I am type O blood. Can she have a second child?

Doctor's answer:

Having a second child involves risks. Whether you are O-type doesn't matter; the key is whether your Rh blood type is positive or negative. If you are also rh-negative, having a second child is not dangerous. If you are rh-positive, then it depends on the Rh blood type of your first child. If the first child is rh-negative, having a second child is not a problem. If the first child is rh-positive, then having a second child is risky. If you are carrying a second child and the baby is rh-negative, there is no danger. If the baby is rh-positive, it is highly likely to cause fetal red blood cell hemolysis.

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