Genetic problem of Down syndrome

Patient's question:

My grandmother had four children in total, among whom the third child, my uncle, has Down syndrome, while the other three are healthy. My mother and aunt are twins and are the firstborn.

Doctor's answer:

Because this condition is a recessive genetic disease, the probability of getting sick is relatively small. If your maternal grandfather does not have this disease, there is no possibility of developing it. So please rest assured.

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